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Basic Science Advances for Clinicians
Fabian Docagne , Jérôme Parcq , Roger Lijnen , Carine Ali , Denis Vivien
Download PDF
Stroke. 2015; 46: 314-320
Fabian Docagne
From the INSERM UMR-S U919 Serine Proteases and Pathophysiology of the Neurovascular Unit, Université Caen Basse Normandie, GIP Cyceron, Caen, France (F.D., J.P., C.A., D.V.); and Center for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium (R.L.).
Jérôme Parcq
From the INSERM UMR-S U919 Serine Proteases and Pathophysiology of the Neurovascular Unit, Université Caen Basse Normandie, GIP Cyceron, Caen, France (F.D., J.P., C.A., D.V.); and Center for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium (R.L.).
Roger Lijnen
From the INSERM UMR-S U919 Serine Proteases and Pathophysiology of the Neurovascular Unit, Université Caen Basse Normandie, GIP Cyceron, Caen, France (F.D., J.P., C.A., D.V.); and Center for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium (R.L.).
Carine Ali
From the INSERM UMR-S U919 Serine Proteases and Pathophysiology of the Neurovascular Unit, Université Caen Basse Normandie, GIP Cyceron, Caen, France (F.D., J.P., C.A., D.V.); and Center for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium (R.L.).
Denis Vivien
From the INSERM UMR-S U919 Serine Proteases and Pathophysiology of the Neurovascular Unit, Université Caen Basse Normandie, GIP Cyceron, Caen, France (F.D., J.P., C.A., D.V.); and Center for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium (R.L.).

Alteplase (Actilyse or Activase) is the gold standard acute treatment of ischemic stroke FAUSTO Slip On Formal Shoes find great online under for sale free shipping low shipping free shipping fast delivery clearance exclusive CDnQnKSG
and receives attention for hematoma resolution in hemorrhagic stroke. The active principle of Alteplase is the recombinant form of an endogenous protease, tissue-type plasminogen activator (tPA). Its intravascular thrombolytic activity is well known, but less are its multifaceted functions in the central nervous system (CNS). Endogenous tPA is not only released in the blood by endothelial cells but also expressed by many cells within the brain parenchyma (online-only Data Supplement), and it can act on all cell types of the brain virtually. Endogenous tPA has been involved in an ever-increasing number of brain functions, of which several are highly relevant during and after stroke. Importantly, knowledge on the mechanisms of action of endogenous tPA may hold true for recombinant tPA.

Sitting out of investing makes the earnings gap between men and women even worse.

The compound interest that comes from investing is so powerful for women, says Katchen, "that if they aren't taking advantage of investments, that pay gap will grow over their earning life."

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, are working to find more seamless ways for people to get over their fears of investing. And they're also rethinking the approach.

"Are we going to retire at 65 as a generation?" asks Katchen. "Probably not."

As a result, the returns model — investing more now so that you'll have a larger reserve in retirement (an approach that motivates Boomers and, to some extent, Gen Xers) — doesn't have as much resonance with Millennials.

Instead, the idea of putting your money toward something good is motivating.

"Millennials think about money differently," says Katchen. "It isn't just about making money, it is about putting their money into causes they believe in and globally investing and putting money into socially responsible investments."

Also, they're committed to financial freedom, he says.

"Young people want to live the lifestyle they want," Katchen says. "Maybe I want that at 40 or 50 or at 80. We've got to figure out a way to engage them on the future, because they aren't set up for it. They aren't set up to have the financial freedom they want."

CNNMoney (New York) First published June 27, 2018: 12:51 PM ET
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Kubernetes is the hottest kid on the block among container orchestration tools right now. I started writing this post when we decided to go with Kubernetes at exclusive sale online clearance cost Skechers Womens Go Walk LiteDaisy Loafer White rdIAd
a year ago, and since then, the developments in the ecosystem have been simply overwhelming. In my opinion, the attention Kubernetes gets is completely deserved, due to the following reasons:

It is a complete solution that is based on a fundamental set of ideas. These ideas are explained in the Soft Style by Hush Puppies Womens Gianna Dress Pump Black Lamy/Patent cheap sale sast clearance limited edition free shipping ebay dODTutEj78
article that compares the consecutive orchestration solutions developed at Google, and the lessons learned.

While it is container-native, Kubernetes is not limited to a single container platform, and the container platform is extended with e.g. networking and storage features.

It offers an open and well-designed API, in addition to various patterns that suit differing workflows. The wonderful thing is that there is a very well-governed community process whereby the API is constantly developed further. You have to spend effort keeping up, but regularly receive goodies in return.

In this tutorial, I want to document my journey of learning Kubernetes, clear up some points that tripped me as a beginner, and try to explain the most important concepts behind how it works. There is absolutely no claim of completeness; Kubernets is way too big for a blog tutorial like this.

Starting off

The easiest way to start using Kubernetes is Minikube. If you have an account with a cloud provider, and would like to first figure out the details of running a cluster on their platform, this tutorial will still work for you, as the commands work for any recent version of Kubernetes. See for details on how to get Minikube running on your computer. In order to manipulate the Kubernetes mini-cluster minikube runs, you need the official CLI client named kubectl, which can be installed following the instructions HUF Mens Classic Lo Ess TX Navy/Cream from china cheap online clearance get to buy kl1xT6Bi
. You will also need Docker to create and push container images. Install Docker on your computer following the instructions .

Once you have installed everything, make sure they are all available with the following commands:

You can check whether Minikube is running using the following command, which also tells you whether there is an update available:

If minikube is not already running, you can start it with minikube start . Normally, when you install minikube, it automatically configures kubectl to access it. You can check whether this is the case with kubectl cluster-info . Its output should be something like the following:

If the IP is not in the 192.168.*.* range, or kubectl complains that configuration is invalid or the cluster cannot be contacted, you need to run minikube update-context to have minikube fix your configuration for you.

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Copyright © McGraw-Hill Global Education Holdings, LLC. All rights reserved.

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